Melanoma Article Summary

Date: 9/30/13
New Target for Melanoma

• Source:
• Location: Sanford-Burnham Medical Research Institute, San Diego, California
What is the article about?
This article is about a team of researchers, led by a man named Ze’ev Ronai, that discovered that a gene encoding an enzyme, phosphoinositide-dependent kinase-1 (PDK1), plays an essential role in the development and progression of melanoma (a deadly form of skin cancer). The team of researchers where injecting mice with lots of the PDK1 into the melanocytes (basically the skin, it is the gene that transforms into melanoma) of the mice. After injecting the PDK1 the researchers injected an anti PDK1 drug called PDK1i, this drug delayed the onset of melanoma lesions and almost completely abolished metastasis of melanoma in the mice. Ronai said that they will be testing the use of the PDK1i in combination with other anti melanoma drugs. Ultimately Ronai believes there research will contribute to better outcomes for patients with melanoma.

What do I think of the article?
I think that this study is just scratching the surface of what will be capable to do with the anti PDK1 drugs in the not to distant future.. The researchers finding offer a new approach to treating melanoma. Not only will these drugs be able to prevent Melanoma cancer but also other types of cancer like pancreatic cancer . Though the drug is only considered to be used as a treatment I think that is just another origin point for a cure for different cancers.